In an interview with Columbia Magazine last year, she said we could be looking at an unprecedented wave of ME/CFS-like illness over the next few years, with profound societal costs. Hornig, who contributed some of the most influential research on ME/CFS in the past decade, helping to establish it as a biological disease, not a psychological disorder, believes research into the overlap between ME/CFS and Long COVID could help millions. Indeed, one might easily ask: could Long COVID and ME/CFS be one and the same? And the onset of both Long COVID and up to 75 percent of ME/CFS cases can be traced to a viral infection. Yet the similarities of Long COVID to ME/CFS are striking, starting with a significant overlap in the symptoms, notably fatigue, unrefreshing sleep or “post-exertional malaise”-a general sense of being unwell after even minor physical or cognitive exertion affecting a majority of those with long COVID, along with high rates of problems with memory and attention (“brain fog”). “We’re really dealing with a mystery right now,” said Koroshetz. But how the virus triggers these symptoms and why it happens in some people not others is so far unknown.
While the condition is most common in those with severe COVID, it is also seen in 19 percent of those with asymptomatic infections, according to an analysis by FAIR Health, although studies vary widely. Individuals with PASC/Long COVID rarely continue to test positive for an active infection (at least by standard tests) but continue to experience a constellation of symptoms, from fatigue to trouble with cognition and chest and abdominal pain. The panel was part of WNYC Radio’s 2021 Health Convening, hosted by Nsikan Akpan, health and science editor at New York Public Radio. Koroshetz, director of the National Institute of Neurological Disorders and Stroke (NINDS), for a late June panel discussion on post-acute COVID. Mady Hornig, a Columbia Mailman School psychiatrist renowned for her research on ME/CFS, joined Walter J. However, one intriguing clue can be found in its similarity to myalgic encephalomyelitis, a disease also known as chronic fatigue syndrome or ME/CFS. Much about Post-Acute Sequelae of SARS-CoV-2 infection (PASC), the clinical term for what is commonly referred to as Long (or Long-haul) COVID, is unknown. By some estimates, nearly a third of people with a symptomatic infection still experience debilitating symptoms months later. Even after the World Health Organization declares the end of the global pandemic, COVID-19 will continue to cast a long shadow.
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